Bond is introduced as both a gambler and an assassin whereas Flandry is neither. The back cover blurb of Baen Books' Young Flandry proclaims:
ENTER DOMINIC FLANDRY -
THE JAMES BOND OF SCIENCE FICTION
- whereas, as the book's compiler and also two blog correspondents have pointed out, the publishing histories show that Flandry preceded Bond by two years.
Flandry is a tragic figure who knows that the Empire he serves is dying whereas Bond lives in a period when, in the words of the Japanese Intelligence chief, Britain has not only lost a great Empire but thrown it away. The Jap refers disparaingly to:
"'...the pitiful ruins of a once great Power.'"
-Ian Fleming, You Only Live Twice (London, 1966), Chapter 8, p. 77.
This reminds us of:
"...the wreckage at the edge of the receding tide of empire." (See here.)
The difference is that the Terran Empire is still only receding.